Endocrine Abstracts

Introduction: Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme involved in folate and homocysteine metabolism. The enzyme is encoded by a gene located on chromosome 1p36.3. MTHFR mutations frequently met in the population are C667T and A1298C. The impairment of homocysteine metabolism due to MTHFR gene polymorphism influences the risk for diseases such as CVS diseases, certain types of cancer and is associated with certain complications of pregnancy inclu...

Background: Clinical experience has shown that men over 60 years of age frequently (40%) require extended intervals of greater than 12 weeks between administrations of Nebido. No work has assessed whether this is specific to men over 60 years of age.Methods: We analysed men on Nebido over 60 years (n=12, mean age 66 years) and compared them with a BMI matched group aged 40–60 years. We assessed testosterone levels, injection intervals, PSA an...

There are very limited data on long-term mortality in pituitary ACTH dependent Cushing’s disease (CD).We report on our data from Stoke-on-Trent, UK, spanning 50 years and provide a meta-analysis of six other reports which addressed mortality of CD. Case records of 60 CD patients from 1958-31 Dec 2009 from Stoke-on-Trent were reviewed. The standardised mortality ratio (SMR) overall and separately for patients in remission and having persistent diseas...

Aim: In normal men testosterone levels fall with age. We wished to assess the efficacy and safety of Nebido in men over the age of 60 years in order to assess dose frequency and other potential complications.Subjects and methods: Ten men over 60 years of age (range 60–77 median 64) with primary or secondary hypogonadism were treated with Nebido 1000 mg i.m. Each was given a loading dose of two injections 6 weeks apart (our normal protocol for all pa...

Recently, low serum adiponectin levels is created as a new risk factor for cardiovascular diseases in climacteric women. Our previous study shows that smoking, serum testosterone levels, blood pressure and BMI have the influence on serum adiponectin levels. Endocannabinoid system plays a role in regulation of food intake and fat accumulation, as well as lipid and carbohydrate metabolism. Menopause transition is related to metabolic disorders (e.g. obesity) and cause the increa...

Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving two or more endocrine glands; MEN 2 is defined by medullary thyroid carcinoma in association with phaeochromocytoma and appears in several clinical variants, which may be inherited as autosomal dominant syndromes. Mutational analysis of RET protooncogene has been use in the diagnosis and management of patients and families with MEN 2 variants.Aim: In this study, we ...

Background: Pleuro-pulmonary inflammatory fibrotic syndrome is a rare but recognised complication of dopamine agonist (DA) therapy in Parkinson’s disease. Here, we describe a case of asymptomatic pulmonary fibrosis, presumed secondary to DA therapy, in a patient treated with cabergoline for an invasive macroprolactinoma.Case report: A 47-year-old previously fit man was admitted as an emergency with a 3 days history of headache followed by collapse. ...

Background: Primary hyperparathyroidism (PHPT) associates many psychiatric symptoms and is therefore important to find out if surgery can alleviates the psychiatric symptoms and improve the quality of patient’s life.Objectives: To study the nature and severity of neuropsychiatric manifestations in patients diagnosed with hyperparathyroidism before and after surgery, as well as to evaluate the correlation of such symptoms with levels of serum calcium...

Objective: To determine the impact of combined antidepressant drugs and LT4 enhancers in treatment of patients with Major Depressive Disorder.Method: We conducted a randomized, placebo-controlled trial to determine whether LT4 supplementation had any augmentation effect on selective serotonin reuptake inhibitors (SSRIs). The study involved 70 patients with major depressive disorder; patients with hypothyroidism were excluded. Of the participants, 38 were...

Objective: Interleukin-6 (IL-6) is an immunoregulative proinflammatory cytokine with pleiotropic functions. It was reported that plasma level of IL-6 in type 1 diabetes mellitus (T1DM) patients was higher than in healthy individuals. IL-6 is supposed to take part in pancreatic beta-cells destruction. So, we considered IL-6 gene to be a candidate one for T1DM. The aim of present study was to investigate the role of IL-6 gene promoter polymorphism in T1DM developme...